相关实验视频
Updated: Jun 7, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.6K
哈西莫托甲状腺炎患者的甲状腺抗体与炎症和多种症状有关
Jiaomei Li1,2, Qingling Huang1, Shuzhen Sun1
1School of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
Scientific reports
|November 13, 2024
概括
哈西莫托甲状腺炎中甲状腺抗体升高与更多的症状和炎症相关,尽管进行激素替代疗法,但影响患者的生活质量.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 哈西莫托甲状腺炎 (HT) 是一种自身免疫性疾病,其特征是甲状腺过氧化酶抗体 (TPO-Ab) 和甲状腺球蛋白抗体 (TG-Ab) 的升高.
- 患者经常经历持续的症状和生活质量的降低,即使有足够的激素替代.
研究的目的:
- 量化甲状腺抗体 (TPO-Ab,TG-Ab) 与HT患者甲状腺外症状,炎症和与健康有关的生活质量之间的关系.
- 为了比较HT患者和健康对照者的症状负担和生活质量.
主要方法:
- 招募了108名HT患者 (高甲状腺状况) 和57名健康对照.
- 对临床参数进行实验室检查.
- 使用哈西莫托甲状腺炎症状问卷评估症状负担,使用SF-36问卷评估生活质量.
主要成果:
- 与对照组相比,HT患者表现出显著更多的甲状腺外症状 (消化,内分泌,神经精神,粘膜皮肤).
- 升高的TPO-Ab和TG-Ab与一般健康和活力相反相关,与促炎因素 (TNF-α,IFN-γ) 有正相关.
- 特定的症状,如腹部膨胀,腹,寒,遗忘,疲劳,抑郁和失眠,与较高的抗体水平有关.
结论:
- 在HT中甲状腺抗体升高与炎症增加和甲状腺外症状的严重程度更高有关.
- 这些抗体会对患者的健康生活质量产生负面影响,强调需要在HT护理中进行全面的症状管理.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.2K
Autoimmune Disorders
390
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
390
Myocarditis II: Clinical features and Diagnostic Tests
2
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
2
Gastritis-II: Pathophysiology
259
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
259
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
117
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
117
Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K

