三糖-葡萄糖指数预测了肝细胞癌的术后整体存活率:一个回顾性队列研究
Gao-Min Liu1,2, Wen-Biao Zhu3, Ji-Wei Xu4,5
1Meizhou Clinical Institute of Shantou University Medical College, No. 38 Huangtang Road, Meizhou, 514000, China.
Discover oncology
|November 13, 2024
概括
甘油三糖 (TyG) 指数可以预测手术后肝癌 (HCC) 患者的整体存活率. 结合TyG指数和TNM阶段的新型诺摩图可能有助于管理HCC预后.
科学领域:
- 肝细胞癌研究 肝细胞癌研究
- 代谢综合征和癌症 代谢综合征和癌症
- 手术瘤学手术瘤学
背景情况:
- 胰岛素抵抗在肝癌 (HCC) 的发展和进展中起着关键作用.
- 非侵入性标记物,如甘油三糖 (TyG) 指数,TG/HDL-c比率和TyG-BMI评估胰岛素耐药性.
- 在接受肝切除术的HCC患者中,这些标志物的预后价值尚未得到充分确立.
研究的目的:
- 在肝切除术后的HCC患者中调查TyG指数,TG/HDL-c比率和TyG-BMI的预后意义.
- 开发和验证HCC患者整体生存期 (OS) 的预测模型.
主要方法:
- 对接受肝切除术的HCC患者的回顾性分析.
- 分类为高指数和低指数组 (TyG,TG/HDL-c,TyG-BMI).
- 使用卡普兰-梅尔分析和考克斯回归的预测评价;名录构造和验证.
主要成果:
- 较低的TyG,TG/HDL-c和TyG-BMI与更糟糕的生存状况有关.
- 与TG/HDL-c和TyG-BMI不同的是,TyG指数独立地预测了OS.
- 一个整合TNM阶段和TyG指数的nomogram显示了HCC OS的良好预测性能.
结论:
- TyG指数是肝切除术后HCC患者的生存状况的独立预测指标.
- 纳入TyG指数的nomogram可能有助于HCC预后管理.
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