人类免疫缺陷病毒的持久性在现役军人群中进行暴露前预防
Jacob T Colver1, Joseph M Yabes2,3, Joseph E Marcus2,3
1Department of Medicine, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, San Antonio, TX, USA. Jacob.t.colver.mil@health.mil.
AIDS and behavior
|November 13, 2024
概括
军事人员显示高人体免疫缺陷病毒暴露前预防 (PrEP) 持久性. 大多数军人继续使用PrEP,性行为的变化是停止使用的主要原因.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 军事医学 军事医学
背景情况:
- 关于人类免疫缺陷病毒暴露前预防 (PrEP) 的使用和在军事群体中的持久性数据有限.
- 人们担心,由于后勤障碍和耻辱,服务人员的PrEP持久性可能会降低.
- 这项研究解决了在军事背景下理解PrEP遵守方面的差距.
研究的目的:
- 评估人类免疫缺陷病毒暴露前预防 (PrEP) 持续率在现役军人中.
- 在这个军事队伍中确定PrEP停药的主要原因.
- 评估前使用者重新开始PrEP的可行性.
主要方法:
- 对2020-2022年期间在军事传染病诊所启动PrEP的现役服务人员的回顾性图表审查.
- 对患者人口统计学,PrEP指示和继续状态的分析.
- 联系那些停止了PrEP的个人,以确定原因并提供重新启动.
主要成果:
- 112名军人接受了PrEP;79%的人在研究结束时仍在服用PrEP,37%的人在其他设施接受了PrEP.
- 准备剂的主要适应症是多个性伴侣与不一致的避孕套使用 (88%).
- 在24名停药者中,有18人被联系;没有人对重新启动PrEP感兴趣,性行为的变化被认为是主要原因.
结论:
- 在这个军事队伍中,PREP的持续率超过了在平民中观察到的水平,尽管存在潜在的系统性挑战.
- 虽然性行为的变化是最常见的停药原因,但系统因素也起到了作用.
- 需要进一步的研究,以充分了解和解决在军事环境中对PrEP护理的障碍.
相关概念视频
Retrovirus Life Cycles
45.7K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.7K
Transmission-based Precautions II: Airborne and Protective Environment
1.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K
Pulmonary Tuberculosis V
170
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
170
Sexually Transmitted Infections
283
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
283
Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220


