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Updated: Jun 27, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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静脉和内GD2-CAR T细胞用于H3K27M+扩散的中线质瘤

Michelle Monje1,2,3,4,5,6, Jasia Mahdi7,8, Robbie Majzner9,8

  • 1Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.

Nature
|November 13, 2024
PubMed
概括

针对GD2 (GD2-CART) 的化学抗原受体T细胞显示出治疗扩散中线质瘤 (DMG) 的前景. 该研究确定了安全的,最高耐受的静脉注射剂量,一些患者经历了显著的瘤减少和神经改善.

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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...