专家对儿童百日咳的共识:诊断和治疗的新概念
Yu-Mei Mi1, Ji-Kui Deng2, Ting Zhang3
1Department of Infectious Diseases, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China.
World journal of pediatrics : WJP
|November 13, 2024
概括
百日咳正在全球复苏,影响儿童和成年人. 这份专家共识提供了关于诊断和治疗百日咳的最新指导,解决了诸如 Bordetella pertussis 抗生素耐药性等挑战.
科学领域:
- 儿童传染病 儿童传染病
- 细菌学 细菌学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 在过去的二十年中,在全球范围内观察到百日咳 (百日咳) 的复苏.
- 尽管儿童普遍接种疫苗,但仍存在控制方面的挑战,可能是由于免疫力下降或 Bordetella pertussis 突变.
- 将疾病负担转移到学龄儿童和成年人身上,他们充当婴儿感染的存储库.
研究的目的:
- 发展专家共识,为临床实践中咳的诊断和治疗提供最新的概念.
- 为应对中国日益严重的抗红素的百日咳 Bordetella (ERBP) 的挑战.
- 为医疗保健专业人员提供全面的参考资料,用于管理儿科 pertussis 病例.
主要方法:
- 专家小组召开会议,审查临床证据,经验和现有指南.
- 在多个数据库 (PubMed,Cochrane,EMBASE等) 进行的系统文献审查. 在2024年5月之前.
- 通过基于收集的证据的开放式讨论,制定建议.
主要成果:
- 建立了百日咳的诊断和治疗流程图.
- 诊断标准,高风险病例的鉴定和严重咳的评估是详细的.
- 治疗建议包括对红素敏感的B. pertussis (ESBP) 的宏类药物,两个月以上儿童的trimethoprim-sulfamethoxazole,以及婴儿和严重病例的静脉注射piperacillin或cefoperazone-sulbactam.
结论:
- 专家的共识为儿童百日咳的诊断和治疗提供了关键的指导.
- 涉及对抗生素敏感和耐药的Bordetella pertussis菌株的临床管理.
- 旨在改善临床环境中的百日咳预防,诊断和管理策略.
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