接种COVID-19疫苗后的姿势静止性心力衰竭综合征:一个系统性审查
Ganesh Bushi1,2, Shilpa Gaidhane3, Suhas Ballal4
1Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Saveetha University, Chennai, India.
BMC cardiovascular disorders
|November 13, 2024
概括
在COVID-19疫苗接种后,发生姿势正静性心动节拍综合征 (POTS) 的风险低于感染SARS-CoV-2后. 需要进一步的研究来了解与疫苗相关的POTS,其机制和长期影响.
科学领域:
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 全球COVID-19疫苗接种已经接种了超过135.3亿剂,大大减少了严重疾病.
- 人们担心潜在的不良影响,包括Postural Orthostatic Tachycardia Syndrome (POTS) 等.
- 本综述系统评估了COVID-19疫苗接种后的POTS发病率,机制和临床影响.
研究的目的:
- 系统地审查和评估COVID-19疫苗接种后POTS的发病率,机制和临床影响.
- 为了比较疫苗接种后的POTS风险与SARS-CoV-2感染后的风险.
- 确定当前的诊断发现和与疫苗相关的POTS的管理策略.
主要方法:
- 在PubMed,EMBASE和Web of Science的系统文献搜索直到2024年6月7日,遵守PRISMA指南.
- 包括各种研究设计:RCT,队列,截面,病例控制,病例系列和病例报告.
- 由两名审查员使用JBI检查清单和NOS进行独立选,数据提取和质量评估.
主要成果:
- 十项研究 (284,678名参与者) 符合纳入标准,包括病例报告,系列和观察/队列研究.
- 队列研究表明,与疫苗接种前相比,疫苗接种后的新POTS诊断的几率比率为1.33.
- 在SARS-CoV-2感染后,POTS的几率为2.11,风险是接种疫苗后的5.35倍;诊断结果包括升的北上腺素和心率变化降低.
结论:
- 与SARS-CoV-2感染相比,COVID-19疫苗接种后POTS的风险较低.
- 目前的研究受到小样本规模和方法异质性的限制.
- 进一步的研究是必不可少的,以澄清疫苗相关POTS的发病率,机制和长期结果,以有效的临床管理.
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