COVID-19和怀孕:对并发症和结果的综合研究
Shang-Ming Zhou1, Hossein Ahmadi2, Lin Huo3
1Centre for Health Technology, Faculty of Health, University of Plymouth, Plymouth, PL4 8AA, UK. shangming.zhou@plymouth.ac.uk.
患有COVID-19的孕妇 (PW) 与非孕妇 (NPW) 相比,面临住院和ICU入院的风险更高. 以前存在的疾病,如免疫抑制和脏疾病显著增加了COVID-19并发症的两组.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 生殖健康 生殖健康
背景情况:
- 怀孕会影响免疫反应和生理变化,可能会改变传染病的易感性和严重程度.
- 了解怀孕,并发症和COVID-19之间的相互作用对于管理生殖年龄妇女的健康结果至关重要.
- 像免疫抑制和脏疾病这样的特定并发症需要在COVID-19的背景下进行专注的调查.
研究的目的:
- 评估怀孕和并发症对生育年龄妇女 (WRA) COVID-19 结果的影响.
- 为了比较孕妇 (PW) 和非孕妇 (NPW) 之间的严重COVID-19并发症风险.
- 为了调查未经研究的并发症:免疫抑制,慢性病和COPD.
主要方法:
- 利用了墨西哥卫生部COVID-19存储库中的7,342,869个WRA的匿名数据.
- 使用描述性统计 (频率,百分比,平均值,标准偏差).
- 从2020年1月到2023年5月的住院和死亡率使用调整的几率比率 (aOR) 评估的关联.
主要成果:
- 孕妇 (PW) 没有更容易感染COVID-19,但面临更高的住院,输管和ICU入院率.
- 免疫抑制增加了PW的COVID-19感染风险,并在非孕妇 (NPW) 中显著增加了死亡率和住院风险.
- 病在PW和NPW中显著增加了COVID-19和全因死亡/住院风险,对NPW的影响更大.
结论:
- 怀孕状态和并发症显著影响WRA.中的COVID-19结果.
- 孕妇COVID-19的管理需要考虑人口因素和先前存在的条件.
- 需要进一步的研究来阐明共患疾病 (如免疫抑制和病) 对COVID-19结果的具体影响.
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