艾滋病毒感染患者的整体手术后手术部位感染的危险因素:一项回顾性研究
Yunzhu Chen1,2, Deli Wu1,2, Qianfeng Zhao1,2
1Department of General Surgery, Zunyi Fourth People's Hospital, Jingwu Road, Honghuagang District, Zunyi, Guizhou Province, 563125, People's Republic of China.
BMC infectious diseases
|November 13, 2024
概括
接受整体手术的艾滋病毒患者面临更高的手术部位感染风险. 第三种类型的切口和白细胞数量的增加是关键的危险因素,而较高的CD4+T细胞数量提供了保护.
科学领域:
- 传染性疾病 传染性疾病
- 手术瘤学手术瘤学
- 免疫学 免疫学 免疫学
背景情况:
- 越来越多的艾滋病毒感染患者需要进行整体手术.
- 与艾滋病毒相关的免疫功能障碍增加了术后手术部位感染 (SSI) 的风险.
- 在HIV阳性手术患者中确定SSI风险因素对于改善结果至关重要.
研究的目的:
- 在接受整体手术的HIV感染患者中调查与手术部位感染 (SSI) 相关的风险因素.
- 确定特定的临床和实验室参数,预测该人群中SSI风险.
主要方法:
- 对125名接受整体手术的HIV感染患者进行了回顾性分析.
- 使用Boruta算法进行变量选.
- 采用单变量/多变量物流回归和受限立方线分析来确定SSI的风险因素.
主要成果:
- 大肠杆菌,肺炎菌和混合细菌是最常见的SSI病原体.
- 第三类手术切口 (OR=9.92) 和手术前白细胞 (WBC) 数量升高 (OR=1.30) 是SSI的独立风险因素.
- CD4+ T 淋巴细胞计数> 400 细胞/μL 证明了对SSI的保护作用 (OR=0.23).
结论:
- 第三种类型的切口和高的手术前白血细胞计数显著增加了艾滋病毒阳性手术患者的SSI风险.
- 较高的CD4+T细胞计数 (>400细胞/μL) 与SSI风险降低有关.
- 优化中性粒细胞,白蛋白,红细胞和尿素的术前水平可能进一步减轻切口感染风险.
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