在动脉样硬化多民族研究中,与降脂疗法相关的因素
Jing Cao1, Weihua Guan2, Sarah O Nomura3
1Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lipids in health and disease
|November 13, 2024
概括
降脂疗法 (LLT) 的不充分使用是常见的. 黑人参与者使用LLT的可能性较低,但冠状动脉 (CAC) 的存在强烈预测了LLT的使用,这表明CAC查可以改善准则的遵守.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 健康差异 在健康上的差异
背景情况:
- 降脂疗法 (LLT) 对于控制动脉样硬化心血管疾病 (ASCVD) 风险至关重要.
- 显著的LLT使用不足影响了美国40%以上的符合条件的个人.
- 关于影响指南指导的LLT使用的可操作因素的研究有限.
研究的目的:
- 在符合治疗条件的个人中确定与LLT使用相关的因素.
- 探索冠状动脉 (CAC) 在预测LLT坚持方面的作用.
- 调查LLT利用中的医疗保健差异.
主要方法:
- 对2010-2012年获得LLT资格的多民族动脉样硬化研究 (MESA) 参与者的分析.
- 参与者在2016-2018年分类为在LLT或非LLT组.
- 多变量相对风险 (RR) 模型评估了LLT使用与人口,临床和CAC因素之间的关联.
主要成果:
- 在2114名符合条件的参与者中,53.4%参加了LLT.
- 黑人参与者使用LLT的比例较低 (RR 0.80).
- 糖尿病 (RR 1.39),高血压 (RR 1.23) 和CAC>0 (RR 1.38) 与LLT使用积极相关.
结论:
- 在MESA队列中确定了影响LLT使用的关键因素.
- 黑人参与者中LLT使用率较低表明医疗保健差异很大.
- CAC测量是改善LLT准则遵守的强有力的可操作预测指标.
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