乳腺癌和易患疾病之间的共同遗传学确定了新的乳腺癌治疗候选人
Panagiotis N Lalagkas1, Rachel D Melamed2
1Department of Biological Sciences, University of Massachusetts, Lowell, MA, USA.
Human genomics
|November 14, 2024
概括
这项研究引入了一种新的方法,通过分析具有易患疾病的共同遗传来识别新的乳腺癌药物重定向候选人. 该方法成功地突出了乳腺癌治疗的现有和拟议的新药物.
科学领域:
- 基因组学和生物信息学
- 翻译性瘤学 翻译性瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 目前的乳腺癌治疗有显著的副作用,需要新的治疗策略.
- 药物重定向提供了一条更快的途径,通过利用具有既定的安全性概况的药物来改善患者护理.
- 抗糖尿病药物梅特福明是针对乳腺癌进行研究的重用药物的例子.
研究的目的:
- 开发一种方法,通过利用具有易患疾病的共同遗传来重新利用乳腺癌的机会.
- 识别与乳腺癌风险和诱导条件相关的类基因,以优先考虑候选药物.
- 突出共享的病因路径,解释药物重新用途的理由.
主要方法:
- 从现有文献中编制了易患乳腺癌的疾病列表.
- 利用全基因组协会研究 (GWAS) 总结统计数据来识别乳腺癌及其易感性疾病之间的共享基因.
- 采用基于网络的方法将共享的基因连接到正规途径,并将药物点与这些途径联系起来.
主要成果:
- 确定了84个基因位置和194个共享基因,表明乳腺癌与其易患疾病之间存在正相关性.
- 通过通路将112种药物中的74种药物与共享基因联系起来,确定它们是重新定位的候选药物.
- 通过发现15种已经处于先进试验或已批准用于乳腺癌的药物来验证该方法,这表明其成功潜力很高.
结论:
- 这种新的方法有效地加速了对乳腺癌的药物重新定位,通过利用与易感条件的共同遗传联系.
- 该研究提供了59种用于乳腺癌重定位的新候选药物,这些药物得到了基础生物见解的支持.
- 这种方法为识别乳腺癌的有效和安全的重新定位疗法提供了一个强大的工具.
更多相关视频
08:15gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
Published on: October 6, 2014
12.2K
07:45Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
5.9K
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Genome-wide Association Studies-GWAS
12.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.5K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Cancer
48.1K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
48.1K
