相关实验视频
Updated: Jun 7, 2025
07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
8.1K
对与香病原发生相关的10 (PR10) 蛋白质变体发生过敏性
Ahmad Husaini Suhaimi1,2, Arullthevan Rajendram3, Fiqri Dizar Khaidizar2
1Biology Division, Centre for Foundation Studies in Science, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Food & function
|November 14, 2024
概括
香病原性相关的-10 (PR10) 蛋白质表现出抗真菌特性,但可能引起过敏. 研究表明,这些蛋白质在26.6%的香过敏患者中具有潜在的过敏性,因此警告不要在食用作物中使用它们.
科学领域:
- 植物分子生物学 植物分子生物学
- 食物过敏研究 食物过敏研究
- 农业生物技术 农业生物技术
背景情况:
- 与致病性相关的-10 (PR10) 蛋白质对于植物对各种压力的防御至关重要.
- 香中的PR10蛋白 (MaPR10-BeB5,MaPR10-GNA5) 具有抗真菌活性.
- 包括Bet v1类家族在内的PR10蛋白与食物过敏有关.
研究的目的:
- 评估香PR10蛋白质 (MaPR10-BeB5和MaPR10-GNA5) 的过敏性潜力.
- 评估暴露于这些蛋白质的香过敏患者发生过敏反应的风险.
主要方法:
- 在IgE表位和蛋白质结构的in silico预测.
- 人类IgE scFv和香PR10蛋白质的分子对接.
- 使用复合蛋白和过敏患者血清进行免疫块分析.
主要成果:
- 香PR10蛋白 MaPR10-BeB5 和 MaPR10-GNA5 被测试的香过敏患者中有26.6%的人识别出来.
- 观察到过敏患者血清对PR10蛋白质的广泛识别.
- 实验数据证实了这些香PR10蛋白的潜在过敏性.
结论:
- 香PR10蛋白 MaPR10-BeB5 和 MaPR10-GNA5 具有过敏原的潜力.
- 建议在粮食作物中使用转基因PR10过度表达时谨慎使用.
- 建议将PR10表达限制在不可食用的植物部分,以减轻过敏风险.
相关概念视频
00:42Cross-reactivity
31.0K
Overview
31.0K
02:06Allergic Reactions
27.2K
Overview
27.2K
01:30Hypersensitivities
522
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
522
01:26Antigens Involved in Adaptive Immunity
460
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
460