了解呼吸系统模型的并发症,作为药物发现的新平台
Simone N De Luca1, Avanka Gunatilaka2,3, Madison Coward-Smith1,4
1Respiratory Research Group, Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, Victoria 3083, Australia.
慢性呼吸道疾病涉及肺和其他器官之间的复杂相互作用. 新的研究探索这些联系和先进的细胞模型,以更好地发现药物和治疗肺部疾病.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 呼吸系统医学 呼吸系统医学
- 病理生理学 病理生理学
背景情况:
- 慢性呼吸道疾病影响全球数百万人,导致大量死亡.
- 目前的治疗主要集中在肺部特异性药物输送上.
- 肺和其他器官之间的双向交声在疾病病理学中至关重要.
研究的目的:
- 审查呼吸系统和受肥胖和动脉样硬化等并发病影响的器官之间的双向关系.
- 讨论新型临床前试验和3D细胞培养模型在疾病洞察力和药物发现方面的潜力.
主要方法:
- 关于肺器官交叉通话的当前科学文献的综述.
- 讨论先进的体外和体内临床前模型.
- 突出了在2023年ASCEPT年度科学会议上提出的研究.
主要成果:
- 在呼吸系统和肺外部之间建立了双向通信通道.
- 确定了复杂的3D细胞培养系统,作为疾病建模的有希望的平台.
- 证明需要改进的临床前模型来研究人类病理生理学.
结论:
- 针对肺部旁边的肺外部部位可能会改善相关并发症的治疗.
- 先进的细胞培养系统为了解疾病机制提供了新的途径,并加速了对呼吸系统疾病的药物发现.
- 进一步开发临床前模型对于有效的治疗策略至关重要.
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