增加了与社会认知,情感和情感价值相关的大脑区域之间的功能连接,在N,N-Dimethyltryptamine (DMT) 诱导的幻觉状态下
Carla Soares1,2, Gisela Lima1,2, Marta Lapo Pais1
1Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute of Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Coimbra, Portugal.
Frontiers in pharmacology
|November 14, 2024
概括
像N,N-Dimethyltryptamine (DMT) 这样的迷幻药物可以通过改变大脑连接来帮助治疗社会情绪缺陷. 这项研究发现,在关键的社会认知和情绪处理大脑区域中,DMT调节了功能连接.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 神经成像是一种神经成像.
背景情况:
- 迷幻药显示出治疗具有社会情绪缺陷的疾病的潜力.
- 休息状态功能磁共振成像 (rs-fMRI) 可以揭示在迷幻状态期间大脑连接的变化.
研究的目的:
- 调查N,N-二甲基三胺 (DMT) 对功能性大脑连接的作用.
- 检查社交认知和情感处理至关重要的领域的连接性.
主要方法:
- 一个对象内药物成像研究,涉及11名健康,经验丰富的用户.
- 使用了N,N-Dimethyltryptamine (DMT) 吸入在活性状态和对照状态.
- 采用以种子为基础的连接性分析,重点关注后部上边缘环和杏仁体.
主要成果:
- DMT增加了后部上边缘回环和前,后部环状回环,杏仁体和轨道前皮层之间的连接性.
- 在杏仁体和轨道前皮层之间也观察到功能连接的增加.
- 在社会情感和情感价值电路中,DMT调节了连接.
结论:
- N,N-Dimethyltryptamine (DMT) 显著改变了对社会认知和情绪处理至关重要的区域的功能性大脑连接.
- 这些发现有助于理解迷幻体验的神经机制及其治疗潜力.
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