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使用自然存在的氨基酸替代物的丁诺芬B变体的结构功能关系

Luca Zangrandi1,2, Barbara Fogli1, Anna Mutti1

  • 1Institute of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

Frontiers in pharmacology
|November 14, 2024
PubMed
概括

研究人员开发了新的迪诺芬B (DynB) 变体,对卡帕阿片类受体 (KOPrs) 具有增强的选择性. 这些DynB衍生物通过最小化与其他阿片类受体的不必要相互作用,显示出有针对性的治疗效果的潜力.

关键词:
与G蛋白结合的受体是G蛋白结合的受体.是一种.功能选择性的功能选择性.类阿片类受体的阿片类受体受体.选择性的选择性

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