对基因饮食治疗由结构性病理引起的耐药性的疗法的有效性和安全性分析
Hongwei Zhang1,2,3,4, Song Su3,4, Huan Zhang3,4
1Department of Neurology, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Frontiers in neurology
|November 14, 2024
概括
性饮食 (KD) 有效治疗结构性原因的儿童的耐药性,也改善了认知和行为症状. 在皮层发育形 (MCD) 中,尤其是焦点皮层发育不良 (FCD) 中,疗效最大.
科学领域:
- 儿科神经学 儿科神经学
- 饮食疗法 饮食疗法
背景情况:
- 结构性病因儿童的耐药性 (DRE) 存在重大管理挑战.
- 性饮食 (KD) 是一种成熟的疗法,但其在结构定义的DRE中的有效性需要进一步阐明.
研究的目的:
- 评估基因饮食 (KD) 的安全性和有效性,对患有因大脑结构异常引起的耐药性 (DRE) 的儿科患者.
- 为了比较不同结构病因之间的KD疗效,并评估相关的认知和行为结果.
主要方法:
- 由于结构性病因而患有DRE的儿童被分为获得性脑损伤和皮质发育形 (MCD) 组.
- 发作频率,不良事件和停止治疗的原因在KD开始后的1,3个月和6个月被监测.
- 评估认知和行为改善,并进行统计分析.
主要成果:
- 没收率分别为4.8%,19%和21.4%在1,3个月和6个月.
- 在同一时间点,整体控制率为42.9%,52.4%和54.8%.
- 患有MCD的组显示出比获得性脑损伤组更高的控制,焦点皮质发育不良 (FCD) 显示出最高的疗效. 在3个月后,69%的患者注意到认知和行为方面的改善. 缺乏疗效和不良遵守是停止治疗的主要原因.
结论:
- 性饮食 (KD) 是对具有结构性病因的儿科耐药性 (DRE) 的安全有效的治疗选择.
- 肯德基提供额外的好处,包括对认知和行为功能的改善.
- 在皮质发育形 (MCD) 组观察到更高的疗效,特别是在焦点皮质发育不良 (FCD),支持这些患者早期考虑KD.
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