与癌症相关的缺血性中风的病原和生物标志物
Gengyu Cen1, Jun Wang1, Xue Wang1
1Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
Journal of inflammation research
|November 14, 2024
概括
与癌症相关的缺血性中风 (CRIS) 可以通过增加中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR),细胞间粘附分子-1 (ICAM-1) 和D-二次体来识别. 这些生物标志物表明,高凝血性和内皮损伤有助于CRIS的发病.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 血液学 血液学 血液学
背景情况:
- 与癌症相关的缺血性中风 (CRIS) 是一个复杂的临床挑战.
- 了解潜在的发病因子和确定CRIS可靠的生物标志物对于患者管理至关重要.
研究的目的:
- 为了研究与癌症相关的缺血性中风 (CRIS) 的致病性.
- 确定可靠的生物标志物,用于早期检测和CRIS风险分层.
主要方法:
- 一项涉及CRIS,仅癌症和仅缺血性中风患者的比较研究.
- 实验室分析包括对D-二聚体和细胞间粘附分子-1 (ICAM-1) 的酶相关免疫吸收试验 (ELISA).
- 评估血液学参数,如中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR).
主要成果:
- 与对照组相比,患有CRIS的患者表现出血红蛋白和淋巴细胞百分比下降,以及中性粒细胞百分比增加和NLR.
- 在CRIS患者中观察到血小板与淋巴细胞比率 (PLR),血球蛋白,前列血时间 (PT),国际正常化比率 (INR) 和ICAM-1的升高.
- 与只有癌症的组相比,在CRIS组中发现了显著更高的D-二聚合物水平.
结论:
- 增加的NLR,PLR,ICAM-1和D-二次体是CRIS的潜在生物标志物.
- 过度凝血和内皮损伤与CRIS的病变发生有关.
- 由于当前研究的样本规模很小,因此需要在大规模前性研究中进一步验证.
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