与诺卡迪亚物种相关的肌肉骨感染:一个病例系列
Ryan B Khodadadi1, Jack W McHugh1, Supavit Chesdachai1
1Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Journal of bone and joint infection
|November 14, 2024
概括
肌肉骨性诺卡迪亚感染很少见,但可能是严重的. 局部感染通常在治疗后得到良好缓解,但传播的诺卡迪亚感染,特别是移植受体,具有很高的死亡风险.
科学领域:
- 传染性疾病 传染性疾病
- 肌肉骨感染 肌肉骨感染
- 医学微生物学 医学微生物学
背景情况:
- 诺卡迪亚物种是肌肉骨感染的不常见原因.
- 现有的文献主要由案例报告组成,限制了对管理和结果的理解.
- 需要进一步的研究来阐明有效的治疗策略和预后.
研究的目的:
- 研究肌肉骨感染的临床特征,管理和结果.
- 确定这些感染的风险因素和预后指标.
- 为了提供对诺卡迪亚肌肉骨感染的有效治疗的见解.
主要方法:
- 进行了一项多中心回顾性队列研究.
- 包括培养证实肌肉骨性诺卡迪亚感染的成年患者.
- 从2011年11月到2022年4月,在三个梅奥诊所中心收集了数据.
主要成果:
- 确定了9例肌肉骨性诺卡迪亚感染病例,主要是男性 (78%).
- 感染情况各不相同,包括败血性关节炎,骨髓炎和骨髓炎. 传播性疾病发生在33%的病例中,特别是在实体器官移植接受者中.
- 一年后的死亡率为22%,仅限于患有扩散性诺卡迪亚感染的患者.
结论:
- 局部化肌肉骨性诺卡迪亚感染通常具有有利的结果.
- 散布的诺卡迪亚感染与明显更高的死亡率有关.
- 治疗常常需要手术干预,并且可能出现复发.
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