调整血糖控制在评估与年龄相关的黄斑退化和糖尿病视网膜病变之间的关系
Michael Wolek1, Brian Wollocko2, Deborah M Li3
1Ophthalmology, University Hospitals Cleveland Medical Center, Cleveland, USA.
与年龄相关的黄斑变性 (AMD) 可能会在II型糖尿病患者中预防糖尿病视网膜病变 (DR). 这项研究发现,AMD诊断与DR的几率显著降低有关,即使控制A1c水平.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 视网膜疾病 视网膜疾病
背景情况:
- 关于与年龄相关的黄斑变性 (AMD) 和糖尿病视网膜病变 (DR) 之间的关系,存在相互矛盾的证据.
- 对于AMD对DR的潜在保护机制尚不清楚.
- 了解这种关联对于管理2型糖尿病患者至关重要.
研究的目的:
- 在II型DM患者中调查AMD和DR之间的关联.
- 在评估AMD-DR关系时控制血糖控制 (A1c).
- 探索人口统计差异和吸烟状况作为二次终点.
主要方法:
- 对461名55岁以上的DMII型患者进行了回顾性分析.
- 根据AMD诊断的存在或不存在来对患者进行分类.
- 使用多变量回归分析来比较DR患病率,控制A1c.
主要成果:
- 118名患者 (25.6%) 被诊断为患有AMD.
- 患有AMD的患者年龄较大,患DR的可能性明显低 (OR 0.35;p<0.001).
- 两组之间没有观察到平均A1c的显著差异.
结论:
- 在这个队列中,AMD诊断与DR的几率相对较低.
- 即使在控制血糖控制 (A1c) 之后,AMD-DR关系仍然存在.
- 在使用DR作为AMD患者糖尿病控制的替代品时,建议小心.
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