生命疲和与心血管风险相关的生物标志物:ARIC研究
Matthew R Deshotels1, Mahmoud Al Rifai2, Caroline Sun3
1Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
JACC. Advances
|November 14, 2024
概括
生命疲,一种慢性压力状态,与较高水平的心血管疾病 (CVD) 生物标志物有关. 识别生命疲和生物标志物升高的个体可以预测心血管疾病事件和死亡率的风险增加.
科学领域:
- 心脏病学 心脏病学
- 精神病体医学是一种精神病体医学.
- 生物标志物研究 生物标志物研究
背景情况:
- 由于慢性压力而导致的疲劳,丧和易怒等特征的生命疲,是心血管疾病 (CVD) 的独立危险因素.
- 了解生命疲和心血管疾病生物标志物之间的联系对于风险评估至关重要.
研究的目的:
- 在大型队列中调查生命疲劳与关键心血管疾病风险生物标志物之间的关联.
- 为了确定生命疲是否预测发生的心血管疾病事件和全因死亡率.
主要方法:
- 在没有患有心血管疾病的社区动脉样硬化风险 (ARIC) 研究中对11,542名参与者的横截面分析.
- 使用马斯特里赫特生命疲劳问卷 (MVEQ) 评估了生命疲劳,并测量了心脏生物标志物:高灵敏度的素T (hs-TnT),N终端亲B型性尿素 (NT-proBNP) 和高灵敏度的C反应蛋白 (hs-CRP).
- 使用Cox比例危险模型进行纵向分析,以评估10年和20年的随访期间发生的CVD事件和所有原因的死亡率.
主要成果:
- 较高的生命疲四分位数与高水平的hs-TnT,NT-proBNP和hs-CRP显著相关.
- 生命疲劳的最高四分位数显示hs-TnT (OR1.75),NT-proBNP (OR1.40) 和hs-CRP (OR1.14) 的可能性增加.
- 严重的生命疲劳症状和高生物标志物的联合存在表明,心血管疾病事件和全因死亡率的风险大大增加.
结论:
- 在中年成年人中,生命疲劳与心血管疾病生物标志物 (hs-TnT,NT-proBNP,hs-CRP) 的升高有关,独立于传统的危险因素.
- 与心脏生物标志物水平一起评估生命疲劳症状可以提高对未来心血管疾病事件和死亡率风险较高的个体的识别.
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