早期胃 papillary 腺癌的内镜和临床病理学特征
Zhenxiang Zuo1, Xing Qi1, Xiujie Cui2
1Department of Gastroenterology, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Frontiers in oncology
|November 14, 2024
概括
早期的胃 papillary 腺癌 (EGPA) 显示出更高的恶性瘤. 升高的,均颜色的内镜病变与上皮圈 (VEC) 内的血管表明EGPA,较小的VEC表明更大的恶性病变.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 胃 papillary 腺癌 (GPA) 的预后比其他差异化类型更差.
- 准确的诊断和活检部位的选择对于GPA管理至关重要.
- 需要对GPA进行内镜检测.
研究的目的:
- 描述早期胃 papillary 腺癌 (EGPA) 的内镜表现.
- 为了区分EGPA和早期胃分化的管状腺癌 (EGDTA).
- 评估表皮圈 (VEC) 结构中的血管与EGPA恶性瘤之间的关系.
主要方法:
- 对46例EGPA和183例EGDTA病例的回顾性分析,这些病例是通过内镜下粘膜解剖 (ESD) 诊断的.
- 倾向分数匹配 (PSM) 用于创建一个由92名EGDTA患者组成的对照组.
- 在ME-NBI下进行多变量后勤回归和VEC结构的评估.
主要成果:
- 与EGDTA相比,EGPA显示出下膜透的增加,成分差异化不良,以及淋巴/血管入侵.
- EGPA病变通常位于胃下部,呈现为均升高的内镜病变,直径更大.
- 在ME-NBI下可视化了VEC结构;较小的VEC与膜下透或差异化组件相关.
结论:
- 而EGPA表现出比EGDTA更高的恶性瘤程度.
- 带有VEC结构的凸起,均色的病变的内镜发现表明EGPA.
- 较小的VEC结构与较高的恶性瘤有关,可以指导活检部位的选择.
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