怀孕期间的贫血:可能与 riboflavin 缺乏有关吗?
Bethany Duffy1, Helene McNulty1, Mary Ward1
1Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, UK.
The Proceedings of the Nutrition Society
|November 14, 2024
概括
低于最佳的利博弗拉状态是怀孕期间贫血的一个未被认可的贡献者,影响铁代谢和红细胞生产. 解决这个缺陷可能会改善母亲和新生儿的健康结果.
科学领域:
- 营养生物化学 营养生物化学
- 孕产妇健康 孕产妇健康
- 血液学 血液学 血液学
背景情况:
- 贫血影响全球超过36%的怀孕,对母亲和新生儿构成风险.
- 缺铁是主要的原因,但其他营养素缺乏,比如利博弗拉 (维生素B2),也与此有关,但研究不足.
- 亚临床 riboflavin 缺乏很普遍,特别是在生育年龄的妇女和怀孕期间,即使在高收入国家.
研究的目的:
- 在不同的人群中审查怀孕期间的 рибофлавин摄入量和状态.
- 评估证据,将 riboflavin 与贫血病的发展和维持血红蛋白水平联系起来.
- 为了突出利博弗拉在预防怀孕相关贫血方面的未被认可的作用.
主要方法:
- 对观察性研究和随机对照试验的系统审查.
- 分析关于孕妇里博弗拉状态,饮食摄入量和血液学参数的数据.
- 检查拟议的连接利博弗拉与铁代谢和红色素形成的生物化学机制.
主要成果:
- 有限的证据表明,低于最佳的黎波弗拉状态会增加高收入人群的贫血风险.
- 在低收入和中等收入国家进行的随机试验表明,补充 рибофлавин可以改善血液状况并减少贫血.
- riboflavin 缺乏症似乎会损害铁代谢,阻碍铁从铁素中释放出来用于红细胞的生产.
结论:
- рибофлавин在怀孕期间维持适当的血红蛋白水平方面起着至关重要的,但经常被忽视的作用.
- 解决亚临床 riboflavin 缺乏症是一个潜在的策略来对抗孕妇的贫血.
- 需要进一步的研究,以充分阐明 рибофлавин对妊娠贫血的影响,并指导公共卫生干预措施.
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