相关实验视频

Updated: Jun 7, 2025

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

目前的焦点治疗在前列腺癌中的作用

Sara Tamburini¹, Lorenzo Bianchi^1,2, Pietro Piazza^1,2

¹Division of Urology, IRCCS Azienza Ospedaliero-Universitaria di Bologna, Bologna, Italy.

|November 14, 2024

概括

前列腺癌 (PCa) 的焦点治疗 (FT) 显示出有希望的功能结果,但与标准治疗相比,缺乏明确的瘤学证据. 在FT在日常实践中得到广泛采用之前,需要更多的研究.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
医疗成像医学成像

背景情况:

多参数磁共振成像 (mpMRI) 改善了前列腺癌 (PCa) 指数病变的检测和定位.
这导致了对PCa微侵袭性焦点治疗 (FT) 的兴趣增加.
然而,与标准治疗相比,FT的最终瘤疗效仍未得到充分报道.

研究的目的:

探索前列腺癌 (PCa) 不同焦点治疗 (FT) 模式的疗效,安全性,瘤和功能结果.

主要方法:

进行了非系统的文献综述.
在PubMed中搜索了关于"前列腺癌"和"焦点治疗"或特定模式 (HIFU,IRE,冷,FLA) 的文章.
包括在2018年至2023年间发表的22篇文章.

主要成果:

焦点疗法包括半离析,焦点离析或向疗法,使用热 (HIFU,冷疗法,RFA,FLA) 或非热 (胸膜疗法,IRE,VTP) 能量.
高强度聚焦超声波 (HIFU) 和冷疗法是最受研究的,比激进治疗显示出潜在的功能益处,但复发/再治疗率更高.
仅有有限的数据可以将FT与标准化激进治疗进行比较.

结论:

目前关于FT结果的证据主要来自回顾性,非比较性,单中心研究.
目前没有焦点治疗被认为是常规实践中标准化治疗的安全替代方案.
FT应保留给经过精心挑选的PCa患者,患有低风险或有利的中期风险疾病,不适合激进选择.

关键词:

这就是HIFU.在PSMA PET/CT中使用.前列腺癌是什么意思前列腺癌是什么意思临床复发临床复发结冷除法结冷除结冷除焦点治疗焦点治疗这个名字是名ogramogram.预测预测预测预测

更多相关视频

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...