可复制性和治疗对办公室和走路压力关系的影响
Giuseppe Mancia1, Rita Facchetti1,2, Fosca Quarti-Trevano3,2
1University Milano-Bicocca, Milan, Italy (G.M., R.F., G.G.).
Hypertension (Dallas, Tex. : 1979)
|November 14, 2024
概括
高血压指南使用基于办公室BP的24小时血压 (BP) 值. 这项研究发现,这些值在接受治疗和未接受治疗的患者之间存在差异,这表明对准确性的估计是分开的.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 临床试验 临床试验
背景情况:
- 目前的高血压指南依赖于从办公室血压测量中得出的24小时门诊血压 (BP) 值,而没有基于结果的试验.
- 目前尚不清楚这些相应的门诊血压值是否在未经治疗和治疗的高血压患者之间是一致的,并且在治疗期间随着时间的推移可以重现.
研究的目的:
- 为了研究未经治疗和治疗的高血压患者在办公室和24小时血压之间的关系.
- 将从这种关系中得出的BP值与当前高血压指南中提供的值进行比较.
主要方法:
- 利用了ELSA和PHYLLIS试验中的2397名患者的数据.
- 计算了办公室缩血压和24小时血压在基线和每年超过3年的治疗期间之间的线性回归关系.
- 确定的24小时BP值与指南定义的办公室BP值相对应.
主要成果:
- 办公室和24小时血压 (心缩和心缩) 之间存在显著的线性关系,尽管相关系数适度 (r ≤ 0.44).
- 这种关系的斜率在治疗期间每年都可重现,但明显低于未接受治疗的个体.
- 与计算值相比,指南中得出的24小时血压值显示出显著的定量和质量差异,特别是在高血压和低治疗目标范围内.
结论:
- 办公室和24小时BP之间的线性回归斜率可在治疗高血压患者的时间内重现.
- 在未经治疗的个体中,更的斜坡表明,为了在未经治疗和治疗的高血压人群中提高准确性,需要单独估计门诊血压值.
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