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在全球范围内,SETDB1活动是由H3K14通过其Triple Tudor域的乙化指导的

Thyagarajan T Chandrasekaran1, Michel Choudalakis1, Alexander Bröhm1

  • 1Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.

Nucleic acids research
|November 14, 2024
PubMed
概括

基因组H3氨酸14乙化 (H3K14ac) 对于SETDB1 (SET域分叉基因组氨酸甲基转移酶1) 的招募和活动至关重要. 这种由SETDB1的Triple Tudor域 (3TD) 介导的相互作用,建立了H3K9三甲基化 (H3K9me3) 基因沉默.

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