通过包括孕妇参与者来照顾孕妇患者
The Journal of clinical ethics
|November 14, 2024
概括
将孕妇排除在临床试验之外,延迟了公共卫生建议. 将它们纳入第二阶段和第三阶段的研究,考虑到妊娠年龄,可以证明疫苗的安全性和有效性.
科学领域:
- 临床研究伦理学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 从历史上看,孕妇被排除在早期临床试验之外,理由是非恶性和胎儿保护.
- 这种排除导致了意想不到的后果,包括推迟对关键干预措施的公共卫生建议.
- SARS-CoV-2 疫苗试验是排除孕妇参与者的下游影响的例子.
研究的目的:
- 建议有意将孕妇参与者纳入II期和III期临床试验设计.
- 重新评估怀孕研究参与者的非有害性之外的伦理框架.
- 探索孕妇如何有助于证明干预措施的安全性和有效性.
主要方法:
- 从第二期和第三期SARS-CoV-2疫苗试验中包括和排除标准的审查.
- 在怀孕的研究参与者的背景下,分析伦理原则,包括非恶性.
- 关于考虑妊娠年龄和干预药理学的替代性包容策略的建议.
主要成果:
- 疫苗试验中的排斥性做法导致推推迟,影响公共卫生工作.
- 孕妇参与者可能有助于实现II期和III期研究的主要目标:安全性和有效性.
- 当前的伦理考虑往往忽视了包括孕妇在内的好处.
结论:
- 怀孕应该被认为是一个人口变量,而不是临床试验中的自动排除标准.
- 伦理框架应该超越非有害性,以纳入更广泛的原则,包括孕妇参与者.
- 蓄意的包容性策略可以改善公共卫生结果,并促进科学理解.
相关概念视频
Parental Care
11.6K
Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
11.6K
Preventive Healthcare Services
972
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
972
Pneumonia V: Nursing management and Prevention
1.9K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
1.9K
Patient-centered Care
2.0K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
2.0K
Standard Precaution
1.9K
Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
1.9K
Planning Nursing Care I
4.3K
The planning phase of the nursing process helps nurses set priorities, outline patient-centered goals and expected outcomes, and tailor nursing interventions to align with the aligned care plan. Through the planning phase, the nurse applies critical thinking skills to align and develop interventions according to the patient's needs. It provides continuity of care allowing patients to receive the maximum benefit from treatment. It serves as a pilot plan for allocating individual staff to a...
4.3K


