怀孕期间母亲的喘和子女神经发育障碍的可能性
Mari Kemppainen1, Mika Gissler2,3,4,5, Turkka Kirjavainen6
1Wellbeing Services County of Vantaa and Kerava, Kivistö Health Station, Vantaa, Finland.
母亲喘与后代神经发育障碍,特别是学习障碍,多动症,运动发育和自闭症的相关性较弱. 绝对流行率差异很小,表明整体影响最小.
科学领域:
- 生殖健康 生殖健康
- 儿科神经学 儿科神经学
- 流行病学 流行病学
背景情况:
- 喘是孕妇中普遍存在的慢性疾病.
- 母亲喘与不良妊娠结果和后代潜在的神经发育问题有关.
- 以前的研究表明,母亲喘和神经发育障碍之间存在联系.
研究的目的:
- 研究母亲喘与后代神经发育障碍风险之间的关联.
- 为了检查在怀孕期间使用喘药物是否会影响这种关联.
- 为了区分过敏和非过敏喘表型之间的关联.
主要方法:
- 一个回顾性基于人口的队列研究.
- 包括来自芬兰的超过127万名母婴夫妇 (1996-2018年).
- 利用了多个高覆盖率的注册表,并调整了考克斯回归模型.
主要成果:
- 母亲喘与ADHD,自闭症,运动,语言,学习和智力障碍的风险增加有关.
- 危险比率在1.12至1.51之间,绝对流行率差异很小.
- 没有观察到过敏和非过敏喘表型之间的显著差异.
结论:
- 孕产妇喘,包括过敏和非过敏类型,与后代神经发育障碍的联系很弱.
- 观察到最强的关联是学习障碍,多动症,运动发育障碍和自闭症.
- 这些发现表明需要对潜在机制进行进一步研究.
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