第一季度环素暴露和重大先天性缺陷的风险
Aya Olivia Nakitanda1, Ingvild Odsbu1,2, Carolyn E Cesta1
1Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
JAMA network open
|November 14, 2024
概括
在瑞典的一项大型队列研究中,对四环素抗生素的第一季度暴露与重大先天性形 (MCMs) 无关. 需要进一步的研究来证实这些发现对于特定的形子组.
科学领域:
- 产科和妇科 产科和妇科
- 儿科健康 儿科健康
- 药物监督 药物监督 药物监督
背景情况:
- 在怀孕期间使用四环素抗生素的安全性数据有限.
- 在第一季度暴露于四环素后,评估重大先天性形 (MCMs) 的风险至关重要.
研究的目的:
- 调查第一季度环素暴露与婴儿MCMs风险之间的关联.
- 分析特定的形子组和个体形,寻找潜在的关联.
主要方法:
- 一项全国性的瑞典队列研究 (2006年7月至2019年12月) 包括单身婴儿.
- 倾向性得分匹配 (1:10) 用于比较暴露和未暴露的婴儿.
- 逻辑二项式回归估计了通过ICD-10代码识别的MCM的相对风险 (RRs).
主要成果:
- 第一个三个月的四环素暴露与任何MCM的风险增加无关 (RR,1.03;95% CI,0.90-1.16).
- 对于特定的四环素物质或大多数形子组/个体形,没有观察到显著增加的风险.
- 在敏感性分析中,神经系统和眼睛异常的风险略微增加.
结论:
- 第一个三个月的四环素暴露似乎不会增加重大先天性形的风险.
- 需要进行进一步的研究,以解决罕见结果和特定形子组的功率限制.
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