在精神分裂症患者中,结构性大脑连接与童年创伤没有关联
Maria R Dauvermann1, Laura Costello2, Leila Nabulsi3
1Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91TK33 Galway, Ireland; Institute for Mental Health, School of Psychology, University of Birmingham, B15 2TT, United Kingdom.
Journal of psychiatric research
|November 14, 2024
概括
儿童创伤没有影响精神分裂症患者的大脑网络差异. 在精神分裂症中观察到结构性连接性变化,但与以前的创伤经历无关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 网络科学 网络科学
背景情况:
- 精神分裂症的特征是大脑失联.
- 儿童创伤 (CT) 对精神分裂症 (SZ) 这种失联性的影响尚未完全理解.
- 这项研究调查了CT对SZ与健康对照 (HC) 的大脑网络拓和结构连接的影响.
研究的目的:
- 为了确定自我报告的童年创伤是否解释了精神分裂症中大脑网络差异的额外变异.
- 为了比较精神分裂症患者和健康对照者之间的全脑拓和结构连接.
- 评估儿童创伤水平和精神分裂症结构网络变化之间的关系.
主要方法:
- 在51 SZ和140 HC评估了童年创伤.
- 使用T1加权MRI和扩散MRI构建结构性大脑网络.
- 分析了整个大脑拓和结构连接的群体差异,并对年龄和性别进行了校正.
主要成果:
- 与对照组相比,精神分裂症患者的网络效率,强度,聚类和密度降低,路径长度增加.
- 在SZ中,在前,前和后子子网络中观察到低连接性.
- 在高的童年创伤水平和精神分裂症的结构网络差异之间没有发现显著的关系.
结论:
- 儿童创伤对精神分裂症的拓或子网络连接变化没有影响.
- 在精神分裂症中证实了网络层面的减少和子网络的改变.
- 研究结果表明,在已确定的精神分裂症中,神经解剖学失联可能不会受到童年创伤的影响.
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