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在不同生长激素受体基因型的男性中,酒精与肺癌风险的关联

Randi Chen¹, Timothy A Donlon², Brian J Morris³

¹Kuakini-Honolulu Heart Program, Center of Biomedical Research Excellence (COBRE) for Clinical and Translational Research on Aging, Department of Research, Kuakini Medical Center, Honolulu, HI, USA.

Lung cancer (Amsterdam, Netherlands)

|November 14, 2024

概括

生长激素受体基因 (GHR) 的遗传变异会影响肺癌风险. 酒精消费显示了GHR-AA基因型的U型风险,但GHR小等位基因载体的风险逐渐增加.

科学领域:

遗传学是一个遗传学.
在瘤学瘤学.
流行病学流行病学

背景情况:

生活方式因素显著影响肺癌 (LC) 风险.
遗传变异,例如生长激素受体基因 (GHR),可能会调节这些效应.
了解这些相互作用对于个性化癌症预防策略至关重要.

研究的目的:

研究GHR基因的遗传变异是否与生活方式因素相互作用,影响男性肺癌风险.
检查GHR单核酸多态 (SNP) rs4130113基因型与LC风险的关联,与酒精消费,BMI,体力活动和吸烟有关.

主要方法:

研究人员对来自日本和夏威夷癌症研究 (Kuakini Honolulu心脏计划) 的6439名男性进行了基于人口的队列研究.
从1965-1968年至1999年12月,对参与者进行了随访,以确定LC和非小细胞LC (NSCLC) 的发病率.
考克斯的比例危险模型被用来评估GHR基因型 (GHR-AA和GHR-G) 和生活方式因素与LC风险之间的关联,调整为共变量.

主要成果:

在长达26.7年的平均随访期内,诊断出190例LC病例.
GHR-G基因型与对LC的保护作用相关 (HR=0.75).
在GHR基因型和酒精摄入量 (p=0.0003) 之间发现了显著的相互作用. 对于GHR-AA,低酒精摄入量 (<2杯/周) 显示最强的LC风险降低 (HR=0.38). 相反,对于GHR-G载体,酒精消费以剂量依赖的方式增加了LC风险 (p趋势=0.005).

结论:

酒精消费对肺癌风险产生不同影响,这取决于GHR基因型.
具有GHR-AA基因型的男性经历了低酒精摄入量的LC风险降低,显示出U形的整体关系.
随着酒精消耗的增加,GHR小等位基因携带者面临着逐渐更高的LC风险.

关键词:

酒精饮料酒精饮料酒精饮料酒精饮料基因与环境的相互作用.生长激素受体的基因型生长激素受体的基因型生活方式生活方式肺癌是一种肺癌.非小细胞肺癌的非小细胞肺癌.

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