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Updated: Jun 7, 2025

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
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Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

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框架和互补性决定区域H1负荷对人类VH-B1a域表达,折叠,稳定性和可溶性的影响

Sharmin Sultana1, C Ronald Geyer2

  • 1Department of Biochemistry, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada.

Biochemical and biophysical research communications
|November 14, 2024
PubMed
概括

通过引入带电氨基酸来改善稳定性和可溶性来设计可变重链 (VH) 域. 带正电荷的框架区域增强了温度稳定性,而CDRH1的修改对中性和带正电荷的域的影响化温度和溶解度不同.

关键词:
在CDRH1中.碎片重新折叠的部分.可溶性 溶解度 溶解度 溶解度热稳定性 热稳定性这是一个VH域名.

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