血小板储存时间对重症患者血小板增加和临床结果的影响 - 一项随机对照试验
Vivek Muraleedharan1, Paramjit Kaur1, Kshitija Mittal1
1Department of Transfusion Medicine, Government Medical College and Hospital, Chandigarh, India.
概括
在ICU患者中,较新血小板 (≤3天) 与较旧的血小板 (4-5天) 相比,显示出更好的血小板增量. 然而,储存时间并没有显著影响出血,感染或死亡率等临床结果.
科学领域:
- 血液学 血液学 血液学
- 输血医学 输血医学
- 密集护理医学 密集护理医学
背景情况:
- 血小板存储时间是可能影响输血疗效和患者预后的关键因素.
- 了解血小板年龄对重症监护室 (ICU) 患者的结果的影响,对于优化输血策略至关重要.
研究的目的:
- 为了研究血小板储存时间对血小板数量增加的影响.
- 评估血小板储存时间对ICU患者临床结果的影响.
主要方法:
- 一个前性,随机的受控试验,涉及需要血小板输血的ICU患者.
- 患者接受了较新鲜的血小板 (≤3天) 或较旧的血小板 (4-5天).
- 评估了血小板增加 (ACI,CCI,PPR) 和临床结果 (出血,感染,ICU停留,死亡率).
主要成果:
- 接受新鲜血小板的患者在输血后24小时显示出明显更高的绝对血小板数量增加 (ACI),纠正数量增加 (CCI) 和血小板恢复率 (PPR).
- 虽然新鲜血小板在1小时后呈现出更高的增量,但这种差异在统计学上并不显著.
- 在临床结果,包括出血率,感染率,ICU停留时间或死亡率等方面,没有观察到两组之间的显著差异.
结论:
- 新鲜血小板的输血导致血小板增加的改善和输血的有效性.
- 血小板存储时间在研究范围内,没有显著改变ICU患者的临床结果或死亡率.
- 同病症和较高的APACHE-III分数被确定为死亡率的独立预测因素.
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