母亲和带血中的金属含量以及胎儿肝功能
Haowei Ma1, Mohammed Ahmed Mustafa2, Marwah Suliman Maashi3
1Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Environmental pollution (Barking, Essex : 1987)
|November 14, 2024
概括
产前接触重金属与胎儿肝酶的增加有关,包括胺转移酶 (GGT),性酸酶 (ALP),氨转移酶 (ALT) 和酸氨转移酶 (AST). (Zn) 显示出保护作用,而 (As), (Cd) 和 (Pb) 与不良结果有关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 围产儿医学 围产儿医学
背景情况:
- 孕妇在怀孕期间接触金属与不良分娩结果有关.
- 金属对胎儿肝功能的具体影响尚不清楚.
- 像GGT,ALP,ALT和AST这样的肝酶是肝脏健康的指标.
研究的目的:
- 为了研究母体和带血金属含量与胎儿肝酶之间的联系.
- 评估金属混合物对腹肝酶的综合作用.
- 为了确定影响胎儿肝功能的特定金属.
主要方法:
- 分析了450名孕妇 (第三季度) 和他们的新生儿的血清样本.
- 在母体和带血中测量13种金属.
- 回归和G-comp分析以检查金属与肝脏酶的关系.
主要成果:
- 增加的母体和带血金属水平与带GGT,ALP,ALT和AST的增加相关.
- (Zn) 在带血中显示与带肝酶的反相关性.
- 金属混合物,特别是 (As), (Cd), (Ni), (Pb), (Hg) 和 (Cr),显著增加了肝酶水平.
结论:
- 产前接触重金属,特别是混合物,可能会对胎儿肝功能产生负面影响.
- 特定的金属如As,Cd,Ni,Pb,Hg和Cr是改变胎儿肝酶水平的关键贡献者.
- 需要进一步的研究,以了解产前金属暴露对胎儿发育的机制和长期影响.
相关概念视频
00:57The Periodic Table and Organismal Elements
176.7K
Overview
176.7K
01:22Development of Immunocompetence
289
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
289