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Updated: Jun 7, 2025

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
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揭示了子酸化表位特异性抗体中高 afinity 和选择性背后的结构机制

Keisuke Kasahara1, Raiji Kawade1, Makoto Nakakido2

  • 1Department of Bioengineering, School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

The Journal of biological chemistry
|November 14, 2024
PubMed
概括

研究人员开发了新的抗体来检测蛋白质酸化,这对于细胞功能和癌症等疾病至关重要. 分子动力学模拟揭示了独特的原子相互作用,驱动高抗体亲和力和对酸化标的选择性.

关键词:
抗体是一种抗体.抗原是一种抗原.分子动力学分子动力学的相互作用 相互作用后翻译修改后的修改.蛋白质结构 蛋白质结构

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