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Updated: Jun 7, 2025

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
09:31

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

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在体外-体内相关性 (IVIVC) 开发的长效注射药物产品,基于多 (lactide-co-glycolide) 基

Yan Wang1, Andrew Otte2, Haesun Park3

  • 1Food and Drug Administration, Center for Drug Evaluation and Research, Office of Generic Drugs, Office of Research and Standards, Silver Spring, MD 20993, USA.

Journal of controlled release : official journal of the Controlled Release Society
|November 14, 2024
PubMed
概括

确定长效注射剂 (LAI) 的体外-体内相关性 (IVIVC) 是至关重要的. 这份对37项研究的综述强调了需要全面的药理动力学数据和释放机制,与预测IVIVC的实时测量相匹配.

关键词:
药物释放介质是药物释放的介质.IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC在体外药物释放测试中进行药物释放测试.可以注射的长效微粒.在 PLGA PLGA 中.

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