来自Atractylodes属的多糖体的提取,分离,结构和生物活动的研究进展:一篇综述
1Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
International journal of biological macromolecules
|November 14, 2024
概括
来自Atractylodes植物的多糖,特别是A. lancea和A. macrocephala,表现出显著的药理作用. 他们的活动与提取方法和结构性质有关,为药物开发提供了潜力.
科学领域:
- 药理学和植物化学
- 自然产品化学 自然产品化学
- 医学植物学 医学植物学
背景情况:
- 植物属Atractylodes (Asteraceae家族) 的植物在传统医学中被使用.
- 它们的根茎含有具有多种药理性质的生物活性多糖.
- 关键物种包括A. macrocephala和A. lancea,它们被广泛研究.
研究的目的:
- 审查Atractylodes多糖的提取,分离和表征方法.
- 分析多糖结构与药理学活动之间的关系.
- 为这些天然化合物的开发和应用提供见解.
主要方法:
- 从Atractylodes物种中提取和分离多糖.
- 物理化学性质的表征:分子量,单糖组成和化学结构.
- 在体外和体内对药理学活性 (免疫调节,抗氧化,抗糖尿病,肠道保护) 的评估.
主要成果:
- 多糖类被确定为Atractylodes中的主要活性成分.
- 药理学活动被证明取决于提取技术和结构特征.
- 对比分析突出了结构与活动的关系.
结论:
- 阿特拉提洛德多糖具有显著的治疗潜力.
- 了解它们的结构特征对于优化它们的药用应用至关重要.
- 这一综述作为未来的研究和开发的参考,以吸引力类衍生产品.
相关概念视频
Cellulose and Pectic Polysaccharides
3.5K
Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth. Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...
As a cell matures, its cell wall specializes according to its type. For example, the...
3.5K
Oligosaccharide Assembly
2.8K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
2.8K
Biosynthesis of Polysaccharides
1
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
1


