微生物组与宿主因子在头癌的发病和治疗中的相互作用
Martina Raudenská1, Maria Bugajová2, David Kalfeřt3
1Department of Pathological Physiology, Faculty of Medicine, Masaryk University/Kamenice 5, CZ-625 00 Brno, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University/Kamenice 5, 62500 Brno, Czech Republic.
Biochimica et biophysica acta. Reviews on cancer
|November 14, 2024
概括
头部和部状细胞癌 (HNSCC) 涉及复杂的相互作用. 准口腔和肠道微生物组为HNSCC管理提供了新的治疗策略,并改善了治疗结果.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 头部和部状细胞癌 (HNSCC) 缺乏强大的驱动突变,使病因学理解复杂化.
- 主体遗传学,生活方式因素 (吸烟,酒精,卫生) 和微生物组之间的复杂相互作用在HNSCC发育中至关重要.
- 肠道微生物组在癌症治疗结果中的作用是一个新兴的研究领域.
研究的目的:
- 在HNSCC中审查宿主和口腔/肠道微生物群之间的双向通信.
- 探索微生物组衍生代谢物对免疫反应和瘤微环境的影响.
- 检查生活方式因素如何塑造微生物组,并影响HNSCC的进展和治疗.
主要方法:
- 文献综述,重点关注HNSCC中的宿主微生物群相互作用.
- 分析微生物组衍生代谢物及其系统性影响.
- 评估生活方式因素对口腔和肠道微生物群组成的影响.
主要成果:
- 微生物组代谢物显著影响系统免疫力,并调节瘤微环境.
- 生活方式因素极大地影响口腔和肠道微生物群,影响癌症的进展.
- 口腔/肠道微生物群是HNSCC治疗疗效的关键决定因素.
结论:
- 口腔和肠道微生物群在HNSCC的发展和进展中发挥着关键作用.
- 准微生物组为HNSCC.提供了一个有希望的治疗途径.
- 调节微生物组可以提高HNSCC患者的癌症治疗结果.
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