两种功能化的减少氧化石墨烯材料的体外毒性,可能在食品包装中应用
Óscar Cebadero-Domínguez1, Leticia Diez-Quijada1, Sergio López2
1Area of Toxicology, Faculty of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain.
概括
食品包装中的功能化石墨烯纳米材料可能带来毒性风险. 研究表明,减少的石墨烯氧化物变体降低了细胞活力和增加了氧化应激,在体外消化后的影响会恶化.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 毒理学 毒理学 毒理学
背景情况:
- 功能化的石墨烯材料增强食品包装纳米复合材料.
- 毒性评估对于与食品接触的材料至关重要.
研究的目的:
- 描述和评估二甲基氨基降解石墨烯氧化物 (DA-rGO) 和二甲基化物降解石墨烯氧化物 (MTAC-rGO) 的毒性.
- 为了评估体外消化对这些石墨烯材料细胞毒性的影响.
主要方法:
- 对DA-rGO和MTAC-rGO的表征.
- 在实验室中评估Caco-2和HepG2细胞系中的物质内化和细胞毒性.
- 材料的体外消化,然后进行表征和细胞毒性评估.
主要成果:
- 对于DA-rGO和MTAC-rGO,细胞活力在100μg/mL下降.
- 观察到氧化应激,由降低的谷氨水平表明.
- 细胞毒性在体外消化后加剧.
结论:
- 功能化石墨烯材料引起了人们对由于细胞毒性而引起的口服暴露的担忧.
- 需要进一步的研究来了解这些材料在食品包装应用中的毒理影响.
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