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Jiayu Feng¹, Yani Huang², Liyan Huang¹

¹Heart Failure Center, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.

BMJ open diabetes research & care

|November 14, 2024

概括

红细胞分布宽度-SD (RDW-SD) 预测了患有糖尿病前期和糖尿病的扩张性心肌病 (DCM) 患者的结果. 它的预后价值在正常血糖DCM患者中是微不足道的,这表明有针对性的治疗的潜力.

科学领域:

心脏病学心脏病学
内分泌学在内分泌学.
炎症生物标志物炎症生物标志物

背景情况:

非缺血性扩张性心肌病 (DCM) 是心力衰竭的重要原因.
红细胞分布宽度-SD (RDW-SD) 是一个新兴的炎症生物标志物.
在DCM患者中,RDW-SD的预后作用在不同血糖状态的DCM患者中是未知的.

研究的目的:

调查RDW-SD在DCM患者的预后意义.
探索RDW-SD与不同血糖状况 (正常血糖,糖尿病前期,糖尿病) 的结果之间的关联.

主要方法:

在2006-2021年期间住院的1,102名DCM患者的回顾性分析.
主要结局:全因死亡率和心脏移植.
根据血糖状况分层的多变量考克斯回归分析.

主要成果:

在整体DCM队列 (aHR 1.29) 中,RDW-SD与不良结果独立相关.
在患有糖尿病前期 (aHR 1.48) 和糖尿病 (aHR 1.30) 的DCM中,预后值显著.
RDW-SD与正常血糖DCM患者的结果没有显著的关联 (aHR 1.20).

结论:

RDW-SD是DCM糖尿病前期和糖尿病患者不良结果的独立预测因子.
这些发现表明,RDW-SD可能有助于识别针对性干预的高风险个体.
血糖状况改变了DCM中的RDW-SD的预后效用.

关键词:

糖尿病 Mellitus,第二种类型.这是心脏衰竭.炎症炎症是一种炎症.在糖尿病前的状态.

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