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Updated: Jun 7, 2025

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

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ISWI1复杂蛋白质促进了Paramecium中的发育基因组编辑

Aditi Singh1, Lilia Häußermann2, Christiane Emmerich2

  • 1Max Planck Institute for Biology, 72076 Tübingen, Germany; estienne.swart@tuebingen.mpg.de aditi.singh@tuebingen.mpg.de.

Genome research
|November 14, 2024
PubMed
概括

两种蛋白,ICOPa和ICOPb,对于纤毛动物的基因组编辑至关重要. 它们与ISWI1相互作用,ISWI1是一种染色体重塑剂,这表明复合物对于在发育过程中精确消除DNA序列至关重要.

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Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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