在内镜切除后的监测中检测到的多个食道状细胞癌的特征
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Updated: Jun 7, 2025

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Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
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Ryo Shimizu1,2, Toshiyuki Yoshio3, Kazunori Hijikata1,2
1Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan.
Esophagus : official journal of the Japan Esophageal Society
|November 14, 2024
概括
对食道癌的内镜切除需要对高风险病变进行仔细监测. 在随访期间,专注于宫/上胸食道和SMT类的升高,以检测转移风险.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 内視鏡外科手術 內視鏡外科手術
背景情况:
- 内镜切除 (ER) 是食道状细胞癌 (ESCC) 的关键器官保护治疗方法.
- 异常慢性 (多重) ESCCs 经常被观察到,需要监测.
- 如果监测不足,一些患者需要在ER后进行额外的治疗.
研究的目的:
- 在内镜监测期间识别高转移风险病变的特征和频率.
- 评估Lugol-voiding损伤 (LVL) 分级和食道胃管透镜 (EGD) 间隔在风险评估中的作用.
主要方法:
- 对956名患者的分析,这些患者在ESCC的ER后至少一年接受了EGD监测.
- 识别具有高转移风险的病变,定义为ESCC,具有亚粘膜或淋巴血管侵袭.
主要成果:
- 多重ESCC的累积发病率在3年后为15.4%,在5年后为22.9%.
- 高转移风险的病变发生在1.0% (3年) 和1.8% (5年) 的患者中.
- 风险因素包括女性性别,宫/上胸部位置,以及下瘤 (SMT) 样边缘升高. LVL等级和EGD间隔没有显著影响高风险病变频率.
结论:
- 内镜监测应优先考虑宫/上胸食道和具有SMT样边缘升高的病变.
- LVL等级和EGD间隔不是高转移风险病变频率的显著预测指标.
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