血红蛋白与红细胞分布宽度比与中风有负相关性:来自NHANESES的横截面研究
Yang Xiong1, Shao Xie1, Yuancheng Yao1
1Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, 99 Huaihai West Road, Xuzhou, 221002, Jiangsu Province, China.
Scientific reports
|November 14, 2024
概括
血红蛋白与红细胞分布宽度比 (HRR) 与中风风险降低有关. 较高的HRR水平表明患中风的可能性降低,特别是在BMI为30或以下的个体中.
科学领域:
- 心血管健康 心血管健康
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 血红蛋白与红细胞分布宽度比 (HRR) 与各种疾病过程有关.
- 之前的研究还没有统计分析HRR和中风之间的关联.
- 了解中风风险的新生物标志物对于公共卫生至关重要.
研究的目的:
- 为了研究血红蛋白与红细胞分布宽度比率 (HRR) 和中风之间的统计联系.
- 探索HRR对中风风险的潜在非线性关系和值影响.
- 检查HRR与中风患病率的BMI依赖性关联.
主要方法:
- 从2005-2018年国家健康和营养检查调查 (NHANES) 中对36215名成年人的横截面分析.
- 通过将血红蛋白 (HGB) 分红细胞分布宽度 (RDW) 来计算HRR.
- 权衡的多变量逻辑回归,通用的添加模型和两部分线性回归来评估HRR-中风关联,包括值效应和BMI的子组分析.
主要成果:
- 在较高的HRR和较低的中风患病率 (P < 0.0001) 之间发现了显著的负相关性.
- 每一次HRR增加1个单位都与中风的可能性降低了58% (OR = 0.42).
- 这种关联依赖于BMI,仅在BMI≤25和25-30时观察到显著的负相关性,在BMI=30时发现值效应.
结论:
- 血红蛋白与红细胞分布宽度比 (HRR) 与中风的可能性有负相关性.
- 较高的HRR水平与中风风险降低相关,特别是在BMI低于30的个体中.
- HRR可以作为中风风险分层的潜在预测生物标志物.
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