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Updated: Jun 7, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

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在全基因组关联研究的元分析中,考虑因环境来源而导致的异质性

Siru Wang1, Oyesola O Ojewunmi2, Abram Kamiza3,4,5

  • 1MRC Biostatistics Unit, University of Cambridge, Cambridge, UK. siru.wang@mrc-bsu.cam.ac.uk.

Communications biology
|November 14, 2024
PubMed
概括

这项研究引入了一种新的统计模型,即环境调整的元回归 (env-MR-MEGA),以改善复杂特征的遗传关联的检测. 它解释了环境和祖先的差异,增强了遗传元分析的力量.

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