抗生素作为糖尿病患者非手术性牙周治疗的辅助剂
Lata Goyal1, Shipra Gupta2, Yeshwanth Perambudhuru3
1Periodontology Division, Department of Dentistry, All India Institute of Medical Sciences, Bathinda, India. latagoyal83@gmail.com.
Evidence-based dentistry
|November 15, 2024
概括
辅助抗生素为糖尿病牙周炎患者提供了轻微的改善,这些患者正在接受缩放和根平 (SRP). 然而,由于抗生素耐药性和副作用,它们的使用需要仔细考虑,应该保留给必要的情况.
科学领域:
- 牙周病学 牙周病学
- 药理学 药理学是指药理学的学科.
- 糖尿病管理 糖尿病管理
背景情况:
- 牙周炎是糖尿病患者常见的并发症.
- 抗生素治疗有时被用作机械牙周治疗的辅助.
研究的目的:
- 系统地审查和元分析辅助局部或全身抗生素在糖尿病患者治疗牙周炎的疗效.
主要方法:
- 在多个数据库 (MEDLINE/PubMed,Scopus,Web of Science) 和灰色文献中进行了全面的文献搜索.
- 包括随机的临床试验比较抗生素辅助缩放和根平整 (SRP) 与单独的SRP.
- 主要结局是临床附着水平;次要结局包括口袋深度,探针出血和牙指数. 使用Cochrane协作工具评估了偏差风险.
主要成果:
- 30项随机临床试验被纳入系统性审查 (27项在元分析中).
- 辅助抗生素,包括局部和全身抗生素,在牙周的临床参数中略有改善.
- 很大一部分研究表现出高偏差风险,特别是那些涉及全身抗生素的研究.
结论:
- 抗生素的辅助使用为糖尿病患者的牙周健康提供了边际益处.
- 对抗生素耐药性和潜在副作用的担忧需要谨慎对待他们的处方.
- 抗生素的使用应仅限于明确表示,好处超过风险的情况.
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