怀孕期间母亲的饮食和后代健康之间的长期联系
Michelle M Murphy1,2,3, Luis Adolfo Santos-Calderón4,5
1Unit of Preventive Medicine & Biostatistics, Faculty of Medicine & Health Sciences, Universitat Rovira i Virgili (URV), Reus, Spain. michelle.murphy@urv.cat.
Pediatric research
|November 15, 2024
概括
根据健康和疾病发育起源假设,孕妇在怀孕期间的饮食和生活方式会影响孩子未来的代谢健康. 需要进一步的研究来证实这些联系,并确定预防慢性疾病的生物标志物.
科学领域:
- 周围生理学 周围生理学
- 发展生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 健康和疾病的发育起源 (DOHaD) 假设认为,终身健康是在胎儿发育期间被编程的.
- 寿命延长导致人口老龄化,慢性疾病发病率上升,给医疗保健系统带来压力.
- 专注于疾病治疗而不是预防,需要对慢性疾病风险的早期暴露进行研究.
研究的目的:
- 审查证据,将怀孕期间母亲暴露与后代代谢健康联系起来.
- 识别由胎儿编程产生的成年期慢性疾病发展的潜在生物标志物.
- 评估有关母亲因素和儿童代谢结果的DOHaD假设研究的现状.
主要方法:
- 在全球范围内对多个母子队列的证据进行系统审查 (例如,GUSTO,COPSAC,MINIMat).
- 包括来自前性观察性研究,随机对照试验和动物研究的数据.
- 分析母亲的饮食,生活方式,营养状况和后代的童年代谢健康之间的关联.
主要成果:
- 来自各种研究的集体证据支持DOHaD假设.
- 怀孕期间母亲的饮食,生活方式和营养状况与儿童代谢健康有关.
- 目前的证据有限,需要进一步调查.
结论:
- 怀孕期间的母亲因素在规划后代的长期代谢健康方面发挥着作用.
- 确定特定的生物标志物对于早期发现和预防成人慢性疾病至关重要.
- 更全面的研究是必不可少的,以加强DOHaD假设的证据基础,并为公共卫生战略提供信息.
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