支气管肺形呼吸和发育 (HYBRiD) 的HYdrocortisone结果研究:一个纵向队列研究的协议
Sara B DeMauro1,2, Haresh Kirpalani3,4, Kristina Ziolkowski3
1Children's Hospital of Philadelphia, Philadelphia, USA. DeMauro@chop.edu.
BMC pediatrics
|November 15, 2024
概括
这项研究跟踪治疗支气管肺功能障碍 (BPD) 的婴儿,以评估长期结果. 它旨在了解BPD和皮质对儿童发展到学龄的影响.
科学领域:
- 新生儿医学 新生儿医学
- 儿科肺病学 儿科肺病学
- 发育儿科 发育儿科
背景情况:
- 支气管肺功能障碍症 (BPD) 显著影响极度早产婴儿,导致长期的呼吸,神经发育和教育挑战.
- 在NICHD新生儿研究网络中,皮质治疗支气管肺形 (BPD) 试验先前评估了皮质在高风险婴儿中的疗效和安全性.
- 皮和BPD严重程度对功能结果的长期影响仍然基本上是未知的.
研究的目的:
- 延长婴儿的随访从Hydrocortisone for BPD试验到早期学龄.
- 描述儿童时期的功能性运动,认知,学术和肺部结果.
- 评估皮暴露和BPD严重程度的长期影响.
主要方法:
- 对于BPD呼吸和发育 (HYBRiD) 结果研究的皮胺注册了最初试验中的幸存儿童.
- 父母在3岁和4岁时填写电话问卷,年龄修正.
- 儿童在早期学龄 (5-7岁校正年龄) 接受面对面的评估,包括功能结果测量和呼吸机制 (在选定的中心).
主要成果:
- 这项研究是对具有重症新生儿肺病史和皮暴露的儿童在学龄期功能性结果的最大评估.
- 数据收集正在进行中,预计这些发现将为长期发展轨迹提供关键的见解.
- 该研究将在这个队列中描述运动,认知,学术和肺功能.
结论:
- 这项HYBRiD结果研究将大大提高对新生儿严重肺部疾病的长期影响的理解.
- 结果将为未来对早产婴儿进行干预试验的设计提供信息.
- 结果将指导有关为有过早生和肺部疾病史的儿童分配资源的公共政策.
相关概念视频
01:26COPD: Management Using Bronchodilators and Corticosteroids
182
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
182
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
222
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
222
01:11Observational Studies
8.2K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
8.2K