高度流行的老年病药物及其对β-粉样纤维素形成的影响
Zakia Zaman1, Radia Islam1, Bhavya Koganti1
1Corewell Health Research Institute, Corewell Health East, 3811 W 13 mile Road, Royal Oak, MI, 48073, USA.
BMC neurology
|November 15, 2024
概括
常见的处方药物,包括维生素D3,Levothyroxine,Prilosec,Flomax和Norvasc,被发现可以在体外抑制阿尔茨海默氏症β-粉样蛋白 (Aβ) 纤维的形成. 这些药物可能会作为多抑制剂,为痴呆症研究提供潜在的新途径.
科学领域:
- 老年医学 老年医学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 全球人口老龄化正面临痴呆症发病率的上升,使老年人中多药的流行率增加.
- 常见药物对阿尔茨海默病 (AD) 病理学的影响,特别是β-粉样蛋白 (Aβ) 纤维素的形成,尚不清楚.
研究的目的:
- 分析患有阿尔茨海默病 (AD),轻度认知障碍 (MCI) 和非痴呆症 (ND) 个体的患者的药物使用情况.
- 研究流行药物对Aβ纤维素形成和神经元毒性的体外影响.
主要方法:
- 收集和分类了124名AD,114名MCI和228名ND患者 (≥65岁) 的药物使用数据.
- 在实验室试验中监测了药物化后的Aβ纤维细胞形成 (使用提奥夫拉T) 和神经元细胞死亡 (使用LDH).
主要成果:
- 在所有队列中,多药性高 (82-90%),最常见的是抗炎,维生素/矿物质和抗胆固醇药物.
- 一些药物,包括维生素D,Levothyroxine,Prilosec,Flomax和Norvasc,在体外显著降低了Aβ纤维素的形成.
- 一些药物对神经元细胞 (N2A,SH-SY5Y) 呈现毒性,Levothyroxine对Aβ介导的毒性表现出保护作用.
结论:
- 通常使用的药物,特别是维生素D3,莱沃西,普里洛塞克,弗洛马克斯和诺瓦斯克,对Aβ纤维素形成具有抑制作用.
- 这些药物可能起到Aβ聚合的多抑制剂的作用,这表明一种潜在的治疗机制.
- 需要进一步的研究来探索这些药物在阿尔茨海默病中的治疗潜力.
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