针对肺癌中的FGF/FGFR信号的临床进展和挑战
Mei Peng1, Jun Deng2, Xiangping Li3
1Department of Pharmacy, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, P. R. China. meipeng@csu.edu.cn.
Molecular cancer
|November 15, 2024
概括
准纤维细胞生长因子 (FGF) 和FGF受体 (FGFR) 信号传导是肺癌的一个有希望的策略. 本综述考察了FGF/FGFR异常,当前的FGFR抑制剂,以及未来的治疗方向.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 纤维细胞生长因子 (FGFs) 和它们的受体 (FGFRs) 调节关键的细胞功能.
- 异常的FGF/FGFR信号,包括过度表达和遗传变化,驱动肺癌的发病,进展和治疗耐药性.
- 目前针对肺癌中的FGF/FGFR信号传导的疗法显示出可变的疗效.
研究的目的:
- 审查肺癌中的FGF/FGFR信号异常.
- 总结各种FGFR抑制剂的临床疗效.
- 讨论在肺癌中准FGF/FGFR的挑战和未来方向.
主要方法:
- 对肺癌中FGF/FGFR信号传递研究的文献综述.
- 对FGFR抑制剂的临床试验数据的分析.
- 讨论治疗策略和挑战.
主要成果:
- FGF/FGFR通路的改变与肺癌的发展和耐药性有关.
- 丁丁达尼布 (Nintedanib) 显示出作为二线肺癌治疗的一些疗效.
- 与其他FGFR抑制剂的临床结果是混合的,突出显示了治疗的复杂性.
结论:
- 向FGF/FGFR信号是肺癌的关键治疗策略.
- 挑战包括患者选择,毒性和抵抗机制.
- 未来的方向包括新型FGFR抑制剂,组合疗法和向FGF带.
更多相关视频
07:39The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
Published on: June 16, 2018
9.2K
09:38Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
Published on: June 26, 2019
7.9K
相关概念视频
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
