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呼吁客观性:放射科医生提出的对固体瘤反应评估的愿望清单 (RECIST 1.1)

Kathleen Ruchalski^1,2, Jordan M Anaokar³, Matthias R Benz^3,4

¹Department of Radiological Sciences, University of California Los Angeles, Los Angeles, USA. kruchalski@mednet.ucla.edu.

Cancer imaging : the official publication of the International Cancer Imaging Society

|November 15, 2024

概括

响应评估固体瘤 (RECIST) 1.1标准为癌症成像评估提供了指导,但依赖于非目标和新病变的主观措施. 纳入对这些的客观评估可以提高解释和临床相关性.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
临床试验临床试验

背景情况:

固体瘤反应评估 (RECIST) 1.1是瘤学临床试验中成像反应评估的标准.
RECIST 1.1客观地定义了目标病变,但依赖于对非目标和新病变的定性评估.

研究的目的:

评估RECIST 1.1的主观评估对图像解释和无进展生存的影响.
探索在RECIST框架内纳入非目标和新病变的更客观措施的潜在好处.

主要方法:

对RECIST 1.1指导方针和文献的审查.
分析非目标和新病变的主观评估如何影响读者变化.
由RECIST工作组考虑之前通过的客观措施.

主要成果:

对非目标和新病变的主观评估引入了读者变异性,可能会影响无进展生存率的确定.
RECIST工作组已经探索了针对非目标和新病变的客观措施.

结论:

对非目标和新病变的客观定义的前性评估可能会改善RECIST 1.1的解释.
增强的RECIST标准可以更好地与临床上有意义的患者结果如生存率和生活质量保持一致.

关键词:

生物标志物,瘤的生物标志物临床试验临床试验是指临床试验的临床试验.疾病进展疾病进展没有进展的生存.拒绝,反对,反对.

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