与调节性T细胞透相关的基于转录组的网络分析确定了RCN1作为清细胞脏细胞癌预后的潜在生物标志物
Yang Qixin1, Huang Jing2, He Jiang1
1Department of Urology, University-Town Hospital of Chongqing Medical University, Chongqing, 401331, P.R. China.
BioData mining
|November 15, 2024
概括
调节性T细胞 (Tregs) 是癌的关键. 这项研究通过分析Treg透和开发预测模型,确定RCN1作为清细胞细胞癌 (ccRCC) 的预后生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 调节性T细胞 (Tregs) 显著影响瘤微环境的免疫抑制性.
- 了解Treg在清细胞细胞癌 (ccRCC) 中的作用对于发现预后标志物和治疗策略至关重要.
研究的目的:
- 调查Treg透在ccRCC中的预后意义.
- 为了确定ccRCC预后和治疗向的潜在生物标志物.
主要方法:
- 权重基因共同表达网络分析 (WGCNA) 在TCGA-KIRC数据中确定了Treg相关的基因模块.
- 共识集群定义了基于Treg透的两个ccRCC集群.
- 一个7基因预后模型被开发和验证为ccRCC总生存预测.
主要成果:
- 基于Treg透的两个不同的ccRCC集群显示了免疫微环境,通路激活,预后和药物敏感性的差异.
- 一个7基因风险评分模型准确地预测了培训和验证队列中的ccRCC预后.
- 确定RCN1是一种可靠的预后因素,主要表达在瘤细胞中,并且与多种癌症的预后不佳有关.
结论:
- 与Treg透相关的预后模型有助于ccRCC临床分层.
- RCN1显示出作为ccRCC的有价值生物标记物的巨大潜力.
相关概念视频
lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K


