作为NCK2调节器的α-synuclein在嗅球中的新功能:对其在嗅觉中的作用的影响
Jing Ren1,2, Chao Wu1,2, Mengxia Zeng1,2
1Department of Neurobiology, Capital Medical University, 10 You'an Men Wai, Xitoutiao, Beijing, 100069, China.
Cell & bioscience
|November 15, 2024
概括
阿尔法-同核素 (Snac) 通过NCK2-依赖的EphA4/RhoA通路调节嗅觉神经元投射. 它的缺乏导致异常投影和嗅觉受损,这可能解释了像帕金森病这样的同核蛋白病变中的嗅觉缺陷.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 阿尔法-同核素 (Snac) 对于理解包括帕金森病在内的同核素病变至关重要.
- 它的生理功能仍然不完全理解,特别是在神经元投射和感官处理方面.
研究的目的:
- 阐明α-synuclein在嗅觉神经元 (OSN) 投影和功能中的生理作用.
- 通过确定α-synuclein影响OSN发育和信号的分子机制.
主要方法:
- 利用alpha-synuclein淘汰赛小鼠研究嗅觉缺陷和异常的神经元投影.
- 采用基于 iTRAQ 的液体染色体质谱法来识别差异表达蛋白质.
- 进行了再表达和过度表达研究,免疫沉和RhoA活性测试.
主要成果:
- 阿尔法同核素的删除导致异常的OSN投影和低血症.
- NCK2被确定为淘汰神经元中显著下调的蛋白质,其缺乏模仿了对EphA4的α-synuclein损失效应.
- 阿尔法-同核素,NCK2和pEphA4水平显著相关;NCK2充当调节EphA4/RhoA通路的支架蛋白,在阿尔法-同核素缺乏的小鼠中活性较低.
结论:
- 阿尔法同核素通过NCK2-依赖的EphA4/RhoA通路调节嗅觉神经元投射.
- 对α-synuclein功能的干扰可能导致异常的嗅觉神经元投射和嗅觉受损.
- 这项研究扩大了对α-synuclein生理作用的了解,并提供了对synucleinopathies嗅觉功能障碍的见解.
相关概念视频
Olfactory Receptors: Location and Structure
8.8K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
8.8K
Olfaction
44.2K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
44.2K
Physiology of Smell and Olfactory Pathway
8.1K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.1K
Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Notch Signaling Pathway
4.2K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.2K
Regulation of Nuclear Protein Sorting
2.4K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.4K


